Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Article Title: Implementation of inpatient models of pharmacogenetics programs

doi: 10.2146/ajhp150946

Figure Lengend Snippet: Comparison of Pharmacogenetic Practice Models at Three Institutions a

Article Snippet: Genotype platform and alleles detected , eSensor XT-8 (GenMark Diagnostics, Carlsbad, CA) CYP2C19*2, CYP2C19*3, CYP2C19*4, CYP2C19*5, CYP2C19*6, CYP2C19*8, CYP2C19*17 , eSensor XT-8 (GenMark Diagnostics) VKORC1 c.-1639G>A; CYP4F2 1347G>A (V433M); CYP2C9*2, CYP2C9*3, CYP2C9*5, CYP2C9*6, CYP2C9*11, CYP2C9*14, CYP2C9*15, CYP2C9*16; CYP2C19*2, CYP2C19*3, CYP2C19*4, CYP2C19*5, CYP2C19*6, CYP2C19*8, CYP2C19*17 , TaqMan (Life Technologies, Foster City, CA) CYP2C19*2, CYP2C19*3, CYP2C19*17.

Techniques: Comparison

Journal: Pharmacogenomics

Article Title: Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation

doi: 10.2217/pgs.12.2

Figure Lengend Snippet: Cardiovascular therapeutics, associated genes and gene variants, associated allele effect and minor allele frequency in different populations.

Article Snippet: In the meantime, the NIH-funded Clinical Pharmacogenetics Implementation Consortium (CPIC) of PGRN has published guidelines to recommend use of genetic information to guide clopidogrel therapy, also noting that the evidence is compelling for a relationship between CYP2C19 genotype and clopidogrel response in acute coronary syndrome patients who have undergone percutaneous coronary intervention [ 35 ]. table ft1 table-wrap mode="anchored" t5 caption a7 Drug Biomarker(s) Label sections † Date of FDA warning † FDA-approved pharmacogenetic testing platforms and assays ‡ Effective date ‡ Clopidogrel CYP2C19 Boxed warning Warnings and Precautions Dosage and Administration March 2010 Affymetrix GeneChip System 3000DX (Roche AmpliChip ® CYP 450 Test) January 2005 AutoGenomics Infiniti ™ Analyzer November 2010 Warfarin CYP2C9 VKORC1 Precautions Dosage and Administration August 2007, updated January 2010 Verigene ® System September 2007 AutoGenomics Infiniti Analyzer January 2008 Cepheid SmartCycler ® Dx System (ParagonDx Rapid Genotyping Assay – CYP2C9 and VKORC1 ) April 2008 Osmetech Molecular Systems eSensor ® XT-8 System July 2008 Roche Diagnostics LightCycler ® Ver1.2 (TrimGen Corporation eQ-PCR ™ LC Warfarin Genotyping Kit) February 2009 GenMark Diagnostics eSensor ® XT-8 System (DNA Genotek Oragene-Dx collection device) December 2011 Open in a separate window † US FDA drug label.

Techniques: Variant Assay

Journal: Pharmacogenomics

Article Title: Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation

doi: 10.2217/pgs.12.2

Figure Lengend Snippet: US FDA warning label for clopidogrel and warfarin and FDA-approved testing platforms and assays for the analyte(s).

Article Snippet: In the meantime, the NIH-funded Clinical Pharmacogenetics Implementation Consortium (CPIC) of PGRN has published guidelines to recommend use of genetic information to guide clopidogrel therapy, also noting that the evidence is compelling for a relationship between CYP2C19 genotype and clopidogrel response in acute coronary syndrome patients who have undergone percutaneous coronary intervention [ 35 ]. table ft1 table-wrap mode="anchored" t5 caption a7 Drug Biomarker(s) Label sections † Date of FDA warning † FDA-approved pharmacogenetic testing platforms and assays ‡ Effective date ‡ Clopidogrel CYP2C19 Boxed warning Warnings and Precautions Dosage and Administration March 2010 Affymetrix GeneChip System 3000DX (Roche AmpliChip ® CYP 450 Test) January 2005 AutoGenomics Infiniti ™ Analyzer November 2010 Warfarin CYP2C9 VKORC1 Precautions Dosage and Administration August 2007, updated January 2010 Verigene ® System September 2007 AutoGenomics Infiniti Analyzer January 2008 Cepheid SmartCycler ® Dx System (ParagonDx Rapid Genotyping Assay – CYP2C9 and VKORC1 ) April 2008 Osmetech Molecular Systems eSensor ® XT-8 System July 2008 Roche Diagnostics LightCycler ® Ver1.2 (TrimGen Corporation eQ-PCR ™ LC Warfarin Genotyping Kit) February 2009 GenMark Diagnostics eSensor ® XT-8 System (DNA Genotek Oragene-Dx collection device) December 2011 Open in a separate window † US FDA drug label.

Techniques: Biomarker Assay, Genotyping Assay